|
週次 |
日期 |
單元主題 |
|
第1週 |
2/21 |
課程導論/
丁致中
Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR–mediated direct in vivo screening
黃馨儀
Fatty acid receptor GPR120 promotes breast cancer chemoresistance by upregulating ABC transporters expression and fatty acid synthesis |
|
第2週 |
2/28 |
228放假 |
|
第3週 |
3/07 |
林郁鈞
Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks
陳彥丞
Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation |
|
第4週 |
3/14 |
劉采晴:
Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance.
陳奕潔:
Separating host and microbiome contributions to drug pharmacokinetics and toxicity. |
|
第6週 |
3/28 |
簡裕峰:
Tracing the transitions from pluripotency to germ cell fate with CRISPR screening.
廖盈瑄:
Engineering of high-precision base editors for site-specific single nucleotide replacement |
|
第8週 |
4/11 |
丁致中:
Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2.
黃馨儀:
Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer. |
|
第12週 |
5/09 |
陳彥丞:
LncRNA NORAD is repressed by the YAP pathway and suppresses
lung and breast cancer metastasis by sequestering S100P
林郁鈞:
Competitive endogenous RNA is an intrinsic
component of EMT regulatory circuits and
modulates EMT |
|
第16週 |
6/06 |
劉采晴:
Pseudogenes Provide Evolutionary Evidence for the Competitive Endogenous RNA Hypothesis.
簡裕峰:
YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells |
|
第17週 |
6/13 |
陳奕潔:
Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension.
廖盈瑄:
Development of hRad51–Cas9 nickase fusions that mediate HDR without double-stranded breaks. |